A Review Of mif reviews

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lately, considerable progress is created in delineating the mechanisms by which inflammatory cytokines and their receptors aid tissue mend and regeneration. This mini review concentrates on rising literature within the position in the cytokine macrophage migration inhibitory element (MIF) and its cell membrane receptor CD74, in preserving against injury and promoting therapeutic in numerous elements of the human body.

MIF can drive its oncogenic signaling through each autocrine and paracrine manners. MIF is known to bind Using the CD74 receptor to activate a number of inflammatory and survival pathways including MAPK and PI3K/Akt7, but the exact molecular system is not absolutely understood. Apparently, CD74 or MIF blockade decreased the aggressiveness of invasive breast cancer cells8.

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